Experimental and computational snapshots of C-C bond formation in a C-nucleoside synthase
The biosynthetic enzyme, ForT, catalyses the formation of a C-C bond between 4-amino-1H-pyrazoledicarboxylic acid and MgPRPP to produce a C-nucleoside precursor of formycin A.The Indoor Area Rug Pad transformation catalysed by ForT is of chemical interest because it is one of only a few examples in which C-C bond formation takes place via an electr